منابع مشابه
Understanding pharmacokinetics/pharmacodynamics in managing neonatal sepsis.
PURPOSE OF REVIEW This review describes recent pharmacokinetic and/or pharmacodynamic studies of antimicrobial agents used for treatment of neonatal sepsis. RECENT FINDINGS Pharmacodynamic targets in adults and neonates with sepsis are likely similar; thus, extrapolations are possible. When using beta-lactams, the free-drug concentration should be maintained above the minimum inhibitory conce...
متن کاملAltered aminoglycoside pharmacokinetics in critically ill patients with sepsis.
The pharmacokinetic disposition of aminoglycosides in critically ill patients with sepsis was studied. In an open-label study of the disposition of gentamicin and tobramycin, individualized pharmacokinetic values of 100 critically ill patients in the surgical intensive-care unit were compared with those of a concurrently monitored group of 100 surgery patients who were not critically ill. The a...
متن کاملLumbar Puncture in Neonates with Sepsis
Introduction: Infections are one of the main causes of death during childhood. Epidemiologic studies in Iran showed that the incidence of neonatal sepsis was 1.8% in 1995. Moreover, the incidence of neonatal meningitis is 0.2 to 0.4 in per 1,000 live births. The aim of this study was to determine the necessity of lumbar puncture (LP) in early neonatal sepsis. Methods: In a retrospective study, ...
متن کاملPharmacokinetics of Piperacillin in Critically Ill Australian Indigenous Patients with Severe Sepsis.
There are no available pharmacokinetic data to guide piperacillin dosing in critically ill Australian Indigenous patients despite numerous reported physiological differences. This study aimed to describe the population pharmacokinetics of piperacillin in critically ill Australian Indigenous patients with severe sepsis. A population pharmacokinetic study of Indigenous patients with severe sepsis...
متن کاملInfluence of sepsis on higher daily dose of amikacin pharmacokinetics in critically ill patients.
BACKGROUND AND OBJECTIVES Severe sepsis is a major problem as cause of high rates morbidity and mortality in intensive care units (ICU). Aminoglycosides are an important group of antimicrobials used for severe sepsis. However, aminoglycoside pharmacokinetics in ICU patients may be altered during sepsis, which can affect the drug concentrations. Therefore, this study was undertaken to examine th...
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ژورنال
عنوان ژورنال: BJA Education
سال: 2019
ISSN: 2058-5349
DOI: 10.1016/j.bjae.2018.09.006